Advances in the treatment of HIV infection with antiretroviral therapy have led to dramatic reductions in opportunistic infections and death. However, late presentation of HIV remains a problem and is a significant contributory cause to death in HIV-seropositive persons in the UK . Furthermore, a recent UK Health Protection Agency (HPA) analysis showed that of 46 700 patients with diagnosed HIV, 19% had CD4 counts o200 cells/mL  and therefore remain at significant risk of opportunistic infection.
These guidelines have been drawn up to help physicians investigate and manage HIV-seropositive patients suspected of, or having an opportunistic infection (OI). They are primarily intended to guide practice in the UK and related health systems.
M Nelson, DH Dockrell and S Edwards on behalf of the BHIVA Guidelines Subcommittee
(See Appendix 2 for list of members of the BHIVA Guidelines Writing Group on Opportunistic Infection)
HIV Medicine (2011), 12 (Suppl. 2), 1-140.