P38 HIV co-receptor tropism prediction remains stable over time in treatment-naïve patients
KEJ Philip¹, M Macartney¹, N Marshall¹, C Smith², M Johnson¹, T Haque¹ and DP Webster^1
1Royal Free Hampstead NHS Trust, London, UK and ²University College London, London, UK

P39 Differences in cART-mediated immune reconstitution are revealed by distinct exhaustive phenotypes of HIV-1- and CMV-specific CD8+ T cells
N Grageda¹, S J Westrop¹, M Nelson², S Mandalia¹, A Jackson², G Moyle² and N Imami^1
1Imperial College London, London, UK and ²Chelsea and Westminster Hospital, London, UK

P40 Emerging patterns of integrase inhibitor resistance
V Nithianathan¹, GKJ Singh², M Bower² and M Nelson^2
1Imperial College School of Medicine, London, UK and ²Chelsea and Westminster Hospital, London, UK

P41 Management of HIV patients on a failing drug regimen: clinical audit and the reanalysis of data by ultra-deep sequencing
V De Sario¹, S Aliyu¹, C Carne¹, F Wilson¹ and J Greatorex^2
1Addenbrooke's Hospital, Cambridge, UK and ²Health Protection Agency, Cambridge, UK

P42 Cellular effects of the antiretroviral drug etravirine in the cardiovascular system
B Desai¹, H Bergin², R Bhokare² and J Mabley^2
1Brighton and Sussex Medical School, Brighton, UK and ²University of Brighton, Brighton, UK

P43 In vitro comparison of the hepatotoxic effects of efavirenz and etravirine on HepG2 cells
V Tilliridou¹, AA Shamsabadi², H Bergin², S Al-Derzi² and JG Mabley^2
1Brighton and Sussex Medical School, Brighton, UK and ²University of Brighton, Brighton, UK

P44 HIV patients with protease inhibitor mutations: Identification of novel Gag mutations and changes in UTR RNA structure using ultra-deep sequencing
L Chanqueo¹, H Martin², K Brugger³, A Rogers³, A Lever¹ and J Greatorex^4
1University of Cambridge, Cambridge, UK, ²Addenbrooke's Hospital, Cambridge, UK, ³EASIH, Addenbrooke's Hospital, Cambridge, UK and ⁴Health Protection Agency, Cambridge, UK

P45 Antiretroviral therapy restores HIV-1-induced abnormal expression of immunoregulatory molecules by plasmacytoid DC
A Benlahrech, A Yasmin, S Westrop, A Coleman, A Herasimtschuk, E Page, P Kelleher, F Gotch, N Imami and S Patterson
Imperial College London, London, UK

P46 Failure to achieve an adequate CD4 count response despite regular engagement in HIV care and consistent viral suppression
J O'Connor¹, C Smith¹, F Lampe¹, M Johnson², C Sabin¹ and A Phillips^1
1UCL Medical School, London, UK and ²Royal Free London NHS Foundation Trust, London, UK

P47 The role of interleukin-6 and interleukin-6 receptor in multicentric Castleman's disease (MCD): frequency of polymorphism
S Mletzko¹, A Rai¹, S Westrop¹, N Imami¹, Y Shahrabi¹, AD Pria², S Howell², M Jones¹, F Gotch¹ and M Bower^2
1Imperial College London, London, UK and ²Chelsea and Westminster Hospital, London, UK

P48 Antiretroviral drugs rilpivirine and efavirenz cause cardiovascular dysfunction: role of endoplasmic reticulum stress
H Bergin¹, M Faltz¹, E Pilavachi² and J Mabley^1
1University of Brighton, Brighton, UK and ²Brighton and Sussex Medical School, Brighton, UK

P49 The use of genotypic tropism testing and maraviroc
R MacKessack-Leitch, K Templeton, J Shepherd, L Renwick and C Leen
NHS Lothian, Edinburgh, UK