19th Annual Conference - Poster Presentations: Basic Science, Immunology and Virology (P38 - P49)

P38 HIV co-receptor tropism prediction remains stable over time in treatment-naïve patients
KEJ Philip1, M Macartney1, N Marshall1, C Smith2, M Johnson1, T Haque1 and DP Webster1
1Royal Free Hampstead NHS Trust, London, UK and 2University College London, London, UK

P39 Differences in cART-mediated immune reconstitution are revealed by distinct exhaustive phenotypes of HIV-1- and CMV-specific CD8+ T cells
N Grageda1, S J Westrop1, M Nelson2, S Mandalia1, A Jackson2, G Moyle2 and N Imami1
1Imperial College London, London, UK and 2Chelsea and Westminster Hospital, London, UK

P40 Emerging patterns of integrase inhibitor resistance
V Nithianathan1, GKJ Singh2, M Bower2 and M Nelson2
1Imperial College School of Medicine, London, UK and 2Chelsea and Westminster Hospital, London, UK

P41 Management of HIV patients on a failing drug regimen: clinical audit and the reanalysis of data by ultra-deep sequencing
V De Sario1, S Aliyu1, C Carne1, F Wilson1 and J Greatorex2
1Addenbrooke's Hospital, Cambridge, UK and 2Health Protection Agency, Cambridge, UK

P42 Cellular effects of the antiretroviral drug etravirine in the cardiovascular system
B Desai1, H Bergin2, R Bhokare2 and J Mabley2
1Brighton and Sussex Medical School, Brighton, UK and 2University of Brighton, Brighton, UK

P43 In vitro comparison of the hepatotoxic effects of efavirenz and etravirine on HepG2 cells
V Tilliridou1, AA Shamsabadi2, H Bergin2, S Al-Derzi2 and JG Mabley2
1Brighton and Sussex Medical School, Brighton, UK and 2University of Brighton, Brighton, UK

P44 HIV patients with protease inhibitor mutations: Identification of novel Gag mutations and changes in UTR RNA structure using ultra-deep sequencing
L Chanqueo1, H Martin2, K Brugger3, A Rogers3, A Lever1 and J Greatorex4
1University of Cambridge, Cambridge, UK, 2Addenbrooke's Hospital, Cambridge, UK, 3EASIH, Addenbrooke's Hospital, Cambridge, UK and 4Health Protection Agency, Cambridge, UK

P45 Antiretroviral therapy restores HIV-1-induced abnormal expression of immunoregulatory molecules by plasmacytoid DC
A Benlahrech, A Yasmin, S Westrop, A Coleman, A Herasimtschuk, E Page, P Kelleher, F Gotch, N Imami and S Patterson
Imperial College London, London, UK

P46 Failure to achieve an adequate CD4 count response despite regular engagement in HIV care and consistent viral suppression
J O'Connor1, C Smith1, F Lampe1, M Johnson2, C Sabin1 and A Phillips1
1UCL Medical School, London, UK and 2Royal Free London NHS Foundation Trust, London, UK

P47 The role of interleukin-6 and interleukin-6 receptor in multicentric Castleman's disease (MCD): frequency of polymorphism
S Mletzko1, A Rai1, S Westrop1, N Imami1, Y Shahrabi1, AD Pria2, S Howell2, M Jones1, F Gotch1 and M Bower2
1Imperial College London, London, UK and 2Chelsea and Westminster Hospital, London, UK

P48 Antiretroviral drugs rilpivirine and efavirenz cause cardiovascular dysfunction: role of endoplasmic reticulum stress
H Bergin1, M Faltz1, E Pilavachi2 and J Mabley1
1University of Brighton, Brighton, UK and 2Brighton and Sussex Medical School, Brighton, UK

P49 The use of genotypic tropism testing and maraviroc
R MacKessack-Leitch, K Templeton, J Shepherd, L Renwick and C Leen
NHS Lothian, Edinburgh, UK