The success of antenatal testing for HIV means that more clinicians than ever are involved in the care of women with HIV who are pregnant. Despite very few recent randomized controlled trials regarding the use of antiretroviral therapy (ART) in pregnancy or obstetric interventions, practice is changing. This is informed largely by observational data and theoretical considerations and these guidelines reflect this. The Cochrane Systematic Review of randomized controlled trials in this area shows how limited the guidelines would be were they to be restricted to such high-level evidence. Changes from the 2005 guidelines include the following.
HIV Medicine (2008), 9, 452-502