We present the updated British Association for Sexual Health and HIV (BASHH) guidelines for post-exposure prophylaxis (PEPSE) to HIV. This document includes a review of the current data to support the use of PEPSE, considers how to calculate the risks of infection after a potential exposure, and provides recommendations on when PEPSE would and would not be considered. We review which agents to use for PEPSE including the potential for drug-drug interactions and make recommendations for monitoring individuals receiving PEPSE. Other areas included are the possible impact on sexual behaviour, cost-effectiveness and issues relating to service provision. Throughout the document, consideration is given to the place of PEPSE within the broader context of HIV prevention strategies and sexual health.
The development of this guideline included a writing group with representatives from the British Association for Sexual Health and HIV (BASHH), British HIV Association (BHIVA), EAGA, Society of Sexual Health Advisers (SSHA), HIV Pharmacy Association (HIVPA), Health Protection Agency (HPA), the HIV and Sexual Health Group of the British Psychological Association, the Terrence Higgins Trust (THT) and the National AIDS Trust (NAT). Patients’ perspectives were considered by involvement of THT, NAT and discussion at a stakeholder group organized by THT and the Community HIV and AIDS Prevention Strategy (CHAPS) conference.
UK guideline for the use of post-exposure prophylaxis for HIV following sexual exposure (2011)