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Are people with HIV and HCV co-infection who are cured of hepatitis C with DAAs at increased risk for liver cancer?
by Liz Highleyman, 2017-02-27 10:30
People with HIV and hepatitis C virus (HCV) co-infection who are successfully treated for hepatitis C using interferon-free direct-acting antiviral (DAA) therapy do not appear to have an increased likelihood of developing hepatocellular carcinoma (HCC), according to a study presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2017) this month in Seattle. More

Bacterial vaginosis does not affect efficacy of oral PrEP in women
by Gus Cairns, 2017-02-23 14:00
Research presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2017) found that the efficacy of oral PrEP for women was not affected by bacterial vaginosis (BV) – the overgrowth in the vagina of untypical microbes.The effectiveness of PrEP in the Partners PrEP study was not significantly different in women with and without

Monoclonal antibodies show promise for HIV-positive people with limited treatment options
by Liz Highleyman, 2017-02-22 12:00
A pair of long-acting monoclonal antibodies that prevent HIV from entering human cells – ibalizumab and PRO 140 – may offer new treatment options for people with highly resistant virus and limited treatment options, researchers reported at the Conference on Retroviruses and Opportunistic Infections (CROI 2017) last week in Seattle. Ibalizumab infusions every two weeks

STI rates in PrEP users very high, but evidence that PrEP increases them is inconclusive
by Gus Cairns, 2017-02-22 12:00
A study of PrEP users presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2017) last week, from CROI’s host city of Seattle, showed that PrEP users had very high rates of STI diagnosis – in the order of 20 times higher than among HIV-negative gay men in the

No evidence of risk compensation after circumcision in three African cohorts
by Roger Pebody, 2017-02-22 09:10
Three large studies in South Africa, Zimbabwe and Kenya have found no evidence that men who have been circumcised have more sexual risk behaviours than uncircumcised men. Two of the studies were reported last week at the Conference on Retroviruses and Opportunistic Infections (CROI 2017) in Seattle; the third was published in the February

Accelerated linkage to HIV care improves retention in care by a third
by Carole Leach-Lemens, 2017-02-21 17:50
Close to 60% of adults benefiting from point-of-care CD4 cell count testing at HIV testing sites, accelerated antiretroviral (ART) initiation and SMS appointment reminders were retained in care after one year, compared to just 44% of those receiving the standard of care (SOC) in Mozambique, according to findings from the Engage4Health study presented last

Better depression care could improve outcomes for HIV treatment programmes
by Roger Pebody, 2017-02-21 16:40
Improved management of depression and other mental health disorders has the potential to improve the outcomes of HIV treatment programmes, Pamela Collins of the National Institute of Mental Health told the Conference on Retroviruses and Opportunistic Infections (CROI 2017) in Seattle last week. Mental health treatment should be integrated into HIV services in resource-limited settings, she said. Diabetes,

Peer navigators improve linkage to HIV care and retention in care in South African study
by Carole Leach-Lemens, 2017-02-21 14:20
Adults recently diagnosed with HIV getting help from peers to address personal barriers to care together with SMS check-in messages, appointment and healthy living reminders had nearly twice the odds of being retained in care at one year follow-up compared to those getting standard of care (SOC) at primary health

Prednisone reduces the risk of developing TB-IRIS after starting antiretroviral treatment
by Keith Alcorn, 2017-02-20 16:30
Prednisone reduces the risk of an immune restoration inflammatory syndrome (IRIS) in people with HIV after starting TB treatment, a randomised trial called PredART has found. The results were presented last week at the Conference on Retroviruses and Opportunistic Infections (CROI 2017) in Seattle, by Dr Graeme Meintjes of the University of Cape Town,

Prednisone reduces the risk of devloping TB-IRIS after starting antiretroviral treatment
by Keith Alcorn, 2017-02-20 16:30
Prednisone reduces the risk of an immune restoration inflammatory syndrome (IRIS) in people with HIV after starting TB treatment, a randomised trial called PredART has found. The results were presented last week at the Conference on Retroviruses and Opportunistic Infections (CROI 2017) in Seattle, by Dr Graeme Meintjes of the University of Cape Town,