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Combination nanotherapy drastically reduces the amount of HIV produced by cells in mice
by Gus Cairns, 2016-02-05 08:40
A combination of fine-particle formulations of the drugs atazanavir and ritonavir, plus an immune-dampener drug designed to induce cells to keep hold of the drugs for longer, has produced a 100-fold decline in the number of CD4 cells in the lymph nodes of mice infected with HIV and an even greater reduction in

Combination nanotherapy drastically reduces the amount of HIV inside cells in mice
by Gus Cairns, 2016-02-05 08:40
A combination of fine-particle formulations of the drugs atazanavir and ritonavir, plus an immune-dampener drug designed to induce cells to keep hold of the drugs for longer, has produced a 100-fold decline in the number of CD4 cells in the lymph nodes of mice infected with HIV. Pre-treatment with the drug also produced infections

Bladder cancer occurring earlier in people with HIV, and cases more difficult to treat, French study finds
by Michael Carter, 2016-02-05 07:20
The frequency of bladder cancer is elevated in patients with HIV, investigators from Paris report in PLoS ONE. Although the malignancy was rare, it often presented in an aggressive form and was associated with poor outcomes. Bladder cancer among patients with HIV mainly involved male patients and occurred at a younger age (mid-50s) than would

Opt-out approach can boost HIV testing rates
by Roger Pebody, 2016-02-04 07:10
A large randomised study in an emergency department in San Francisco clearly shows that an ‘opt-out’ approach to seeking consent for HIV testing can increase the number of people who take the test.The proportion tested ranged from 38% to 66%, depending on the wording used by staff offering HIV testing, Juan Carlos Montoy

Broad range of risk factors associated with mild cognitive impairment in HIV-positive men on ART
by Michael Carter, 2016-02-03 10:30
A broad range of factors are associated with cognitive impairment in middle-aged HIV-positive men, according to Dutch research published in the online edition of AIDS. The observational, cross-sectional, case-controlled study involved antiretroviral-treated participants with sustained viral suppression. Reduced cognitive function was associated with cannabis use, depression, metabolic factors and previous HIV-related immune suppression.  “Decreased cognitive performance probably

Tenofovir resistance may develop after HIV treatment failure in over half in sub-Saharan Africa
by Keith Alcorn, 2016-02-01 17:30
More than half of people who experienced failure of a tenofovir-based antiretroviral regimen in sub-Saharan Africa had resistance to tenofovir, a meta-analysis of drug resistance studies published in Lancet Infectious Diseases has shown. The TenoRes collaborative study was designed to assess the prevalence of tenofovir resistance in people experiencing failure of first-line treatment. Tenofovir is

Tenofovir resistance may develop in more than half of patients failing treatment in sub-Saharan Africa
by Keith Alcorn, 2016-02-01 17:30
More than half of people who experienced failure of a tenofovir-based antiretroviral regimen in sub-Saharan Africa had resistance to tenofovir, a meta-analysis of drug resistance studies published in Lancet Infectious Diseases has shown.The study found that the prevalence of tenofovir resistance after first-line failure ranged from 20% in Western Europe and North

New Merck combination pill Zepatier approved for hepatitis C treatment in the United States
by Keith Alcorn, 2016-02-01 10:50
Merck has received a US license for its direct-acting antiviral combination of grazoprevir and elbasvir, to be marketed as Zepatier. The combination of grazoprevir (an HCV protease inhibitor) and elbasvir (an NS5A inhibitor) is dosed once daily for 12 weeks or 16 weeks with or without ribavirin. The combination has been approved for the treatment

Criminal laws on HIV transmission make little difference to sexual behaviour – or may make condomless sex more likely
by Roger Pebody, 2016-02-01 10:00
A study comparing the sexual behaviour of American gay men living in states with or without laws that criminalise HIV transmission has found very little variation by state, suggesting that legislation has minimal impact on public health. Or the law may be counter-productive – men who believed they lived in a state which criminalised HIV transmission